NRF2 Pathway – Tapping Your Greatest Inner Defense
Our NRF2 pathway is our inner unsung hero. Here, we are presenting research so that we all optimize & celebrate our unknown gift. Let’s make activating our NRF2 pathway #1 on our bucket list. How many of the other items on our wish lists are feasible without our health?
Harvard Health on Inflammation: A unifying theory of disease. Research is showing that chronic inflammation may be the common factor in many diseases”
What is the NRF2 Pathway?
The Nrf2 pathway, or signaling system controls the expression of many antioxidant and detoxification genes, by binding to antioxidant response elements (AREs) that are DNA sequences that respond to dietary antioxidants. In simple terms, NRF2 is a system from within that helps lower chronic inflammation by providing cells access to an abundance of antioxidants, to extinguish the flames of oxidative stress and inflammation.
NRF2 turns on our production of the 3 main antioxidants ( catalase, glutathione and SOD) having a 1 million to one advantage over ingesting individual antioxidants.
Washington State University 2015: “NRF2 may well become the most extraordinary therapeutic and most extraordinary preventative breakthrough in the history of medicine”
Research on Covid-19, Immune response & lung function
Why we want to activate our NRF2 Pathway:
Pubmed studies oxidative stress and diseases
Free Radicals, Oxidative Stress and Antioxidants in Human Disease
Are there Possible implications of the NRF2 pathway for Covid-19? 2018 study from Oxidative Medicine & Cellular Longevity:
Therapeutic Modulation of Virus-Induced Oxidative Stress via the Nrf2-Dependent Antioxidative Pathway
Inflammation and Recovering from Covid-19
“After any severe case of pneumonia, a combination of underlying chronic diseases and prolonged inflammation seems to increase the risk of future illnesses, including heart attack, stroke, and kidney disease” Sachin Yende, epidemiologist and critical care physician, University of Pittsburgh Medical Center
Heart disease is the leading cause of death: NRF2 and heart disease
The Role of Nrf2 in Cardiovascular Function and Disease 2017
Nrf2 as a Potential Mediator of Cardiovascular Risk in Metabolic Diseases 2019
Nrf2 at the heart of oxidative stress and cardiac protection
NRF2 and Depression:
The Role of Oxidative Stress in Anxiety Disorders
Osteoarthritis and NRF2 activation
Cancer & Oxidative Stress
Oxidative stress, inflammation, and cancer: How are they linked?
Correlation between Oxidative Stress, Nutrition, and Cancer Initiation
NRF2 and Neurodegenerative Disorders
NRF2 Activation Protective effects on the lung disorders, pathogenesis of respiratory diseases 2019
Respiratory Complications with HIV
Potential Protective and Therapeutic Roles of the Nrf2 Pathway in Ocular Diseases: An Update 2020: (Eye health)
OK…You get the idea…..Oxidative stress leading to chronic inflammation is at the root of our chronic illnesses, mental and physical.
There are thousands of more studies available on the importance of lowering oxidative stress and activation of the NRF2 pathway.
I urge everyone to examine their choices. As we study oxidative stress and inflammation, we realize that sometimes, our best intentions with our health, can actually increase oxidative stress and chronic inflammation.
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Lower oxidative stress, Redefine Your healthy Lifestyle, from your DNA!
Shira has been in chronic care management and prevention for 30 years, researcher, specializing in lifestyle habits including holistic nutrition, medical fitness and oxidative stress reduction. She is frequently called upon by the media, has her own podcast bringing current research to the public.
She has created and provided oxidative stress assessments, to help clients identify potential health risks. From these, she designs appropriate exercise and physical activity protocols, nutrition ideas for lowering inflammation and to fall in love with fitness.
Articles featured in: Corporate Wellness Association, European Registry of Exercise Professionals, The National Post, Investment Executive Magazine, Directory of Greater Toronto, Canadian Leukemia & Lymphoma Association, Prostate Cancer Canada, Multiple Sclerosis Society of Canada, Anytime Fitness, Today’s Black Woman, Today’s Seniors, Medical Fitness Network, FORCE (Facing Our Risk of Cancer Empowered), Willow (Breast & Hereditary Cancer Support),Myeloma Canada, Cancer Exercise Training Institute, Urban Poling for Breast Cancer, ROW – Recovery on Water for Breast Cancer, Sirius XM Doctor Radio, Medical Fitness Network
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