Tag Archives: proactive health

NRF2 Pathway Defining Proactive Health

NRF2 Pathway – Tapping Your Greatest Inner Defense

Our NRF2 pathway is our inner unsung hero. Here, we are presenting research so that we all optimize & celebrate our unknown gift. Let’s make activating our NRF2  pathway #1  on our bucket list.  How many of the other items on our wish lists are feasible without our health?

Harvard Health on Inflammation: A unifying theory of disease. Research is showing that chronic inflammation may be the common factor in many diseases”

What is the NRF2 Pathway?

NRF2 pathway to prevent disease Best In Corporate Health

The Nrf2 pathway, or signaling system  controls the expression of many antioxidant and detoxification genes, by binding to antioxidant response elements (AREs) that are DNA sequences that respond to dietary antioxidants. In simple terms, NRF2 is a system from within that helps lower chronic inflammation by providing cells access to an abundance of antioxidants, to extinguish the flames of oxidative stress and inflammation.


NRF2 turns on our production of the 3 main antioxidants ( catalase, glutathione and SOD) having a 1 million to one advantage over ingesting individual antioxidants.

Washington State University 2015: “NRF2 may well become the most extraordinary therapeutic and most extraordinary preventative breakthrough in the history of medicine”

Research on Covid-19, Immune response & lung function

Why we want to activate our NRF2 Pathway:

Pubmed studies oxidative stress and diseases

Free Radicals, Oxidative Stress and Antioxidants in Human Disease

Are there Possible implications  of the NRF2 pathway for Covid-19?  2018 study from Oxidative Medicine & Cellular Longevity:

Therapeutic Modulation of Virus-Induced Oxidative Stress via the Nrf2-Dependent Antioxidative Pathway

Inflammation and Recovering from Covid-19

NRF2 pathway Inflammation in lungs from Covid-19
chronic lung inflammation in Covid-19

“After any severe case of pneumonia, a combination of underlying chronic diseases and prolonged inflammation seems to increase the risk of future illnesses, including heart attack, stroke, and kidney disease”  Sachin Yende, epidemiologist and critical care physician, University of Pittsburgh Medical Center


Heart disease is the leading cause of death: NRF2 and heart disease

NRF2 and metabolism

The Role of Nrf2 in Cardiovascular Function and Disease 2017 

Nrf2 as a Potential Mediator of Cardiovascular Risk in Metabolic Diseases 2019

Nrf2 at the heart of oxidative stress and cardiac protection

NRF2 and Depression:

Live a Healthy Lifestyle activating your NRF2 pathway

NRF2 and mood disorders 


The Role of Oxidative Stress in Anxiety Disorders



Osteoarthritis and NRF2 activation



Cancer & Oxidative Stress

Oxidative stress, inflammation, and cancer: How are they linked?

Correlation between Oxidative Stress, Nutrition, and Cancer Initiation


NRF2 and Alzheimer’s

NRF2 and Neurodegenerative Disorders

NRF2 Autism

NRF2 Activation Protective effects on the lung disorders, pathogenesis of respiratory diseases 2019

Respiratory Complications with HIV

Potential Protective and Therapeutic Roles of the Nrf2 Pathway in Ocular Diseases: An Update 2020: (Eye health)

OK…You get the idea…..Oxidative stress leading to chronic inflammation is at the root of our chronic illnesses, mental and physical.

There are thousands of more studies available on the importance of lowering oxidative stress and activation of the NRF2 pathway.

I urge everyone to examine their choices. As we study oxidative stress and inflammation, we realize that sometimes, our best intentions with our health, can actually increase oxidative stress and chronic inflammation.

 Book a consult, provide employees with our OS assessment, a very different approach to corporate health!

Lower oxidative stress, Redefine Your healthy Lifestyle, from your DNA! 

Are you worth $40/month?

Happily explain.

Shira Litwack, Corporate Program Designer
Shira Litwack, BSc, Corporate Wellness Specialist, Chronic Care recovery, medical exercise, holistic nutrition, addiction recovery

In Health,

Shira Litwack

Shira has been in chronic care management and prevention for 30 years, researcher,  specializing in lifestyle habits including holistic nutrition, medical fitness and oxidative stress reduction. She is frequently called upon by the media, has her own podcast bringing current research to the public.

She has created and provided oxidative stress assessments, to help clients identify potential health risks. From these, she designs appropriate exercise and physical activity protocols, nutrition ideas for lowering inflammation and to fall in love with fitness.

Articles featured in:  Corporate Wellness Association, European Registry of Exercise Professionals, The National Post, Investment Executive Magazine, Directory of Greater Toronto, Canadian Leukemia & Lymphoma Association, Prostate Cancer Canada, Multiple Sclerosis Society of Canada, Anytime Fitness, Today’s Black Woman, Today’s Seniors, Medical Fitness Network, FORCE (Facing Our Risk of Cancer Empowered), Willow (Breast & Hereditary Cancer Support),Myeloma Canada, Cancer Exercise Training Institute, Urban Poling for Breast Cancer, ROW – Recovery on Water for Breast Cancer, Sirius XM Doctor Radio, Medical Fitness Network

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Corporate Responsibility And Health Centricity

Corporate Responsibility Through Preventative Healthcare

Enabling corporate responsibility is our duty as anyone who services the corporate world… third party advisors, HROs and  yes, corporate wellness providers. We lead   people to  healthier, happier more productive  lives,  fulfilling on many levels a large part of corporate responsibility. Connecting employee health to larger societal health is vital. We all know the studies,  healthy employees are more productive, less absenteeism and presenteeism. … As a company develops a more holistic understanding of how health and wellness are linked to other important social and environmental challenges, and business challenges, it creates an awakening to the many intricacies and facets of employee health. Where many corporate health models sabotage their own success – is weak follow through.

  • presenting in a manner that is supportive of participation
  • enabling implementation and adherence
  • incentivizing ➪for continual support  and adherence & creating a corporate health culture

Our  current model of healthcare is sick care, and sadly, employers are drowning by following this same path. Health care dollars are usurped from a reactive, episodic acute care model, and of course the long term needs and dollars of chronic care. We can find different dollar values thrown around, depending on which of the thousands of costs are being tallied, but suffice it to say chronic care costs, between care and lost productivity hundreds of billions yearly.

The massive opportunity for the health of society and our economy:

 Preventive healthcare

Leading healthier lives (which is a sweeping statement)  and stopping the onset of illness is the holy grail of healthcare transformation and sustainability. It is  the ultimate investment companies can make.  We all agree we are only as strong, resilient and energized as our people.

In terms of corporate health, the model of preventive care can be further defined for implementation and precision:

Proactive care solutions: Providing solid, science based knowledge of healthier living, helping employees with implementation, adherence, provides a health centric motivating environment to respect the endless value of health.  A proactive approach also ensures that preventive action is taken to intervene well before the onset of symptoms, far before illness. Proactive health should not be confused with diagnostics, which are a part of proactive health, but certainly not the only aspect of a proactive process.

Predictive care solutions leverage cutting-edge health technologies and sophisticated gathering of  data to not only stratify risk, but even predict risk and intervene even further upstream. This can be done through effective health risk assessments (HRA), metrics and reporting from the proactive tools.  Predictive care solutions available  and are a lost opportunity for health when not implemented. With the increased collection of personal health and lifestyle data and improved analytics, we can generate accurate insights earlier. This  allows us to anticipate issues, pinpointing where behavioural intervention is needed and provide actions to take before risk factors even arise.

NCD: Non-infectious and non-transmissible diseases that may be caused by genetic or

Corporate Responsibility Preventative health employee wellness Best In Corporate Health
Breakdown NCD: Courtesy World Economic Forum

behavioral factors and generally have a slow progression (could have been incubating for years  in which hopefully identified and prevented) and long duration. These include cardiovascular diseases, cancer, chronic respiratory diseases, and diabetes. According to the CDC, 80% of chronic illness is lifestyle, behavioral, however, people need to be made aware of what many of these behaviors and exposures are. 

According to a study released in 2011 by the World Economic Forum, Harvard School of Public Health “The U.S. Government and Global Non-Communicable Disease (NCD) Efforts”:

  • NCDs are the leading causes of death and disability globally, killing more than three in five people worldwide and responsible for nearly half of the global burden of disease.
  • Among the leading causes of preventable illness and related disability
  • Cardiovascular diseases, cancer, chronic respiratory diseases, and diabetes account for about 80% of NCD deaths
  • NCDs are responsible for 3.9 million deaths each year in the Region of the Americas, representing 3⁄4 of all deaths.
  • An estimated 200 million people in the Americas are living with NCDs, which has a tremendous impact on their life, well-being, and ability to work. This, in turn, poses major challenges to the economy, the health system and other sectors of society.
  • If  modifiable risk factors  (behavioral) were eliminated, 80% of all heart disease, stroke, and type 2 diabetes would be prevented and over 40% of cancer would be prevented.
  • The causes of NCDs and their risk factors are largely determined by the social, physical and economic environment. Thus, combating NCDs requires action on the social determinants in a person’s environment, not just healthcare. Creating healthy environments and making healthy choices available and known, are critical.

Just a scary stat: Diabetes and Insulin, our master hormone: $245 Billion, Annually . Diabetes is 90% preventable

Conclusion from World Economic Forum study on Non Communicable Diseases:

A final thought: Economic policy-makers are naturally concerned about economic growth. The evidence presented in this report indicates that it would be illogical and irresponsible to care about economic growth and simultaneously ignore NCDs. Interventions in this area will undeniably be costly. But inaction is likely to be far more costly.

Corporate wellness programs are potentially an affordable, very effective way to reduce the economic, personal and social burden of illness. Shifting to a preventive paradigm requires a holistic and employee-centred approach that involves participation  and dedication from employers and employees. Again, we need to provide programs that

  • Provide solid science
  • Assess employee needs
  • Is supportive of corporate responsibility
  • Teach, don’t preach
  • Interaction on numerous levels vital to learning and sustainability
  • Engage the employee to participate
  • Models a corporate loyalty to the employee
  • Creates camaraderie & passion  to infuse  the corporate health culture
  • Inclusive of the science of change and behavioral modification
  • Implementation  – providing employees the guidance for adherence, work/life integration, organization and time
  • Is inclusive of family support
  • Incentivize the employee for participation in a manner that is supportive of the employee’s health efforts and the health centric environment of the company
  • It HAS to be fun, invigorating, encouraging…not another miserable obligation and time demand in the employee’s life

Follow the hard science.  A number of vague studies have been  released stating that proactive health and wellness programs do not really impact the corporate bottom line. Where these  myopic snapshot falls short…. …what are they measuring? Do they have an accurate, measurable value, scientific means of data collection as to illnesses that were prevented? Were they categorizing all corporate wellness initiatives into one lump? What were the measures of adherence?  For these studies to deny the impact of preventative health education and implementation, is to deny greater studies lead by global health researchers and organizations….. Science proves that a strong proactive model for health which preempts illness, acute and chronic, is vital for health and economics.

World Health Organization on Corporate Responsibility:

Corporate Responsibility Best In Corporate Health
Courtesy World Health Organization

“The workplace directly influences the physical, mental, economic and social well-being of workers and in turn the health of their families, communities and society. It offers an ideal setting and infrastructure to support the promotion of health of a large audience. The health of workers is also affected by non-work related factors.”

“A health-promoting workplace recognizes that a healthy workforce is essential and integrates policies, systems and practices conducive to health at all levels of the organization. Rather than a series of projects, workforce health promotion is an ongoing process for improving work and health.”

Providing health information is a start, but only a start. Corporate responsibility affects:  shareholders, customers, suppliers, employees and their families, communities, financiers, society…..and of course their own survival. The impact of health is omnipotent.

Corporate Responsibility with Health….Best In Corporate Health

The supplement like a flu shot against oxidative stress…..

Why are we not controlling chronic illness? We must control the wildfire of inflammation and lower oxidative stress. We know oxidative stress is at the root of chronic illness such as cancer, heart disease, depression, diabetes, arthritis….. inflammation ages us and leaves us susceptible to disease. ….We take a flu shot to prevent the flu – one simple supplement to lower your oxidative stress by as much as 40%.    7 patents, 24 peer reviewed studies on pubmed, accolades from American Heart Association, Mayo Clinic, National Institute on Aging….Washington State: “may well become the most extraordinary therapeutic and most extraordinary preventative breakthrough in the history of medicine.”

Shira Litwack, Corporate Program Designer
Shira Litwack, medical fitness professional, Cancer Exercise Specialist , Medical Exercise Specialist, Holistic Nutritionist

Chief Health Enthusiast – Best In Corporate Health

Employee Wellness Toronto, Ontario – But offered worldwide!

  • Shira is regularly consulted by Naturopaths, oncologists, health coaches on cancer exercise and exercise adherence.
  • Has assembled over 20 health and fitness professionals with varying specialties to bring to corporate wellness programs
  • Platforms include: Speaking, One-one/group health coaching, Retreats, Course development for in house delivery, Metrics to measure success available, Partners always included
  • Now offering live interactive webinars, just as if each participant has a personal health coach – making corporate wellness programs affordable to all.
  • Shira has been interviewed & published in hundreds of resources over the last 12 years:

Articles featured in: ezines, ArticlesInk, European Registry of Exercise Professionals, The National Post, Investment Executive Magazine, Directory of Greater Toronto, Canadian Leukemia & Lymphoma Association, Prostate Cancer Canada, Multiple Sclerosis Society of Canada, Anytime Fitness, Today’s Black Woman, Today’s Seniors, Medical Fitness Network, FORCE (Facing Our Risk of Cancer Empowered), Willow (Breast & Hereditary Cancer Support),Myeloma Canada, Cancer Exercise Training Institute, Urban Poling for Breast Cancer, ROW – Recovery on Water for Breast Cancer, Sirius XM Doctor Radio